HTR1B Polyclonal Antibody for Human(Homo sapiens) | EIAab.comHTR1B Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > HTR1B(Gene name) > Human

HTR1B (Gene name),

5-hydroxytryptamine receptor 1B (Protein name ), 5HT1B_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

HTR1B(HTR1DB);

Protein name:

5-hydroxytryptamine receptor 1B(5-HT-1B;5-HT1B);

Alternative:

Serotonin 1D beta receptor(5-HT-1D-beta);S12;Serotonin receptor 1B;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

390

Sequence:

50:

100:

150:

200:

250:

300:

350:

390:

FDFFTWLGYL | NSLINPIIYT | MSNEDFKQAF | HKLIRFKCTS |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P28222

KEGG:

hsa:3351

UniGene:

Hs.123016

SMR:

P28222

Pfam:

PF00001

STRING:

9606.ENSP00000358963

MIM:

182131

Uniprot:

P28222

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ELISA Kit for Human 5-HT-1B

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ELISA Kit for Human 5-HT-1B

Cat.:

E10279h

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96T

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ELISA Kit for Human 5-HT-1B

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ELISA Kit for Human 5-HT-1B

Cat.:

E10279m

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ELISA Kit for Human 5-HT-1B

Cat.:

E10279r

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96T

ELISA Kit for Human 5-HT-1B

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CLIA Kit for Human 5-HT-1B

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CLIA Kit for Human 5-HT-1B

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CLIA Kit for Human 5-HT-1B

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CLIA Kit for Human 5-HT-1B

Cat.:

U10279m

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Packing:

96T

CLIA Kit for Human 5-HT-1B

Cat.:

U10279r

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MSDS:

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Packing:

96T

CLIA Kit for Human 5-HT-1B

Cat.:

U10279h

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Polyclonal Antibody for Human 5-HT-1B

Cat.:

P10279Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human 5-HT-1B

Protein for Human 5-HT-1B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity."
Hamblin M.W. , Metcalf M.A. , McGuffin R.W. , Karpells S.
Biochem. Biophys. Res. Commun.184:752-759(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION;SUBCELLULAR LOCATION
2.

"Cloning and expression of the human 5-HT1B-type receptor gene."
Mochizuki D. , Yuyama Y. , Tsujita R. , Komaki H. , Sagai H.
Biochem. Biophys. Res. Commun.185:517-523(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION;SUBCELLULAR LOCATION
3.

"Characterization of the human 5-hydroxytryptamine1B receptor."
Jin H. , Oksenberg D. , Ashkenazi A. , Peroutka S.J. , Duncan A.M.V. , Rozmahel R. , Yang Y. , Mengod G. , Palacios J.M. , O'Dowd B.F.
J. Biol. Chem.267:5735-5738(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
4.

"Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype."
Levy F.O. , Gudermann T. , Perez-Reyes E. , Birnbaumer M. , Kaumann A.J. , Birnbaumer L.
J. Biol. Chem.267:7553-7562(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION;SUBCELLULAR LOCATION
5.

"Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta."
Weinshank R.L. , Zgombick J.M. , Macchi M.J. , Branchek T.A. , Hartig P.R.
Proc. Natl. Acad. Sci. U.S.A.89:3630-3634(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION
tissue: Placenta.
6.

"A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6."
Demchyshyn L. , Sunahara R.K. , Miller K. , Teitler M. , Hoffman B.J. , Kennedy J.L. , Seeman P. , van Tol H.H.M. , Niznik H.B.
Proc. Natl. Acad. Sci. U.S.A.89:5522-5526(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
7.

"Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype."
Veldman S.A. , Bienkowski M.J.
Mol. Pharmacol.42:439-444(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION;SUBCELLULAR LOCATION
8.

"Human-specific amino acid changes found in 103 protein-coding genes."
Kitano T. , Liu Y.-H. , Ueda S. , Saitou N.
Mol. Biol. Evol.21:936-944(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
9.

"Isolation of complete coding sequence for 5-hydroxytryptamine (serotonin) receptor 1B (HTR1B)."
Kopatz S.A. , Aronstam R.S. , Sharma S.V.
Submitted (2003-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
10.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
12.

"Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition."
Ng G.Y.K. , George S.R. , Zastawny R.L. , Caron M. , Bouvier M. , Dennis M. , O'Dowd B.F.
Biochemistry32:11727-11733(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION;PHOSPHORYLATION;FUNCTION
13.

"Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed."
Xie Z. , Lee S.P. , O'Dowd B.F. , George S.R.
FEBS Lett.456:63-67(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;SUBCELLULAR LOCATION
14.

"Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect."
Edvinsson L. , Uddman E. , Wackenfors A. , Davenport A. , Longmore J. , Malmsjo M.
Clin. Sci.109:335-342(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
15.

"Serotonin receptors."
Nichols D.E. , Nichols C.D.
Chem. Rev.108:1614-1641(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
16.

"Serotonin receptors - from molecular biology to clinical applications."
Pytliak M. , Vargova V. , Mechirova V. , Felsoci M.
Physiol. Res.60:15-25(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
17.

"Structural features for functional selectivity at serotonin receptors."
Wacker D. , Wang C. , Katritch V. , Han G.W. , Huang X.P. , Vardy E. , McCorvy J.D. , Jiang Y. , Chu M. , Siu F.Y. , Liu W. , Xu H.E. , Cherezov V. , Roth B.L. , Stevens R.C.
Science340:615-619(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
18.

"Structural basis for molecular recognition at serotonin receptors."
Wang C. , Jiang Y. , Ma J. , Wu H. , Wacker D. , Katritch V. , Han G.W. , Liu W. , Huang X.P. , Vardy E. , McCorvy J.D. , Gao X. , Zhou X.E. , Melcher K. , Zhang C. , Bai F. , Yang H. , Yang L. , more...
Science340:610-614(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 33-390 IN COMPLEXES WITH ERGOTAMINE AND DIHYDROERGOTAMINE;FUNCTION;SUBCELLULAR LOCATION;MEMBRANE TOPOLOGY;DOMAIN;DISULFIDE BOND;MUTAGENESIS OF LEU-126; ASP-129; ILE-130; CYS-133; THR-134; VAL-200; VAL-201; THR-203; THR-209; SER-212; ALA-216; TRP-327; PHE-330; PHE-331; SER-334; MET-337; PHE-351; ASP-352; THR-355 AND TYR-359
19.

"Identification of genetic variation in the human serotonin 1D beta receptor gene."
Nothen M.M. , Erdmann J. , Shimron-Abarbanell D. , Propping P.
Biochem. Biophys. Res. Commun.205:1194-1200(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYS-124

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